Stemetil
Tablet
Generic Name
Prochlorperazine Maleate
Strength
5 mg
Manufacturer
Synovia Pharma PLC.
Unit Price
Unit Price: ৳ 0.65 (30 x 20: ৳ 390.00) Strip Price: ৳ 13.00
🔹 Indications
🔹 Pharmacology
Prochlorperazine is a dopamine & histamine antagonist. The mechanism of antiemetic activity is due to the blockade of histamine H, & dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre. It also has a weak anticholinergic effect and prevents acid reflux by increasing the tone of the lower oesophageal sphincter.
🔹 Dosage & Administration
Antiemetic-
Children (not recommended in children <10 kg or <2 years):
Antipsychotic-
Children (not recommended in children <10 kg or <2 years):
Nonpsychotic anxiety-
Children (not recommended in children <10 kg or <2 years):
- 10-14 kg: 2.5 mg every 12-24 hours as needed;maximum: 7.5 mg/day
- 15-18 kg: 2.5 mg every 8-12 hours as needed;maximum:10 mg/day
- 19-39 kg: 2.5 mg every 8 hours or 5 mg every 12 hours as needed; maximum: 15 mg/day.
Antipsychotic-
Children (not recommended in children <10 kg or <2 years):
- 2-12 years: 2.5 mg 2-3 times/day
- Increase dosage as needed to a maximum daily dose of 20 mg for 2-5 years and 25 mg for 6-12 years
Nonpsychotic anxiety-
- Adults: Usual dose: 15-20 mg/day in divided doses; do not give doses >20 mg/day or for longer than 12 weeks
- Elderly: Initial: 2.5-5 mg 1-2 times/day; increase dose at 4 to 7 day intervals by 2.5-5 mg/day; increase dosing intervals (twice daily, thrice daily, etc) as necessary to control response or side effects; maximum daily dose should probably not exceed 75 mg in elderly; gradual increases (titration) may prevent some side effects or decrease their severity.
🔹 Interaction
Alcohol, barbiturate & other sedatives may increase the CNS depressant action. Some drugs like Antacids, antiparkinson's drug, lithium may interfere the absorption of Stemetil. Stemetil may interfere with the plasma concentration of Propanolol and Phenobarbital.
🔹 Contraindications
Hypersensitivity to prochlorperazine or any component of the formulation, severe CNS
depression; coma; should not be used in children <2 years of age or <10 kg.
depression; coma; should not be used in children <2 years of age or <10 kg.
🔹 Side Effects
Drowsiness; jaw, neck, and back muscle spasms; fine worm-like tongue movements; rhythmic face, mouth, or jaw movements; slow or difficult speech; difficulty swallowing; restlessness and pacing; tremors; shuffling walk; skin rash; yellowing of the skin or eyes.
🔹 Pregnancy & Lactation
No evidence of adverse effects of this drug has been reported during pregnancy & lactation.
🔹 Precautions & Warnings
Caution should be taken while performing tasks that require alertness, such as driving or using machinery. The use of alcohol can cause extreme drowsiness. This medication may increase sensitivity to sunlight. Prolonged sun exposure should be avoided and sunscreen and protective clothing should be taken when anybody is exposed to the sun. This medication can reduce sweating making it more susceptible to heatstroke.
🔹 Storage Conditions
Store below 30°C.Protect from light and moisture. Keep out of the reach of children.
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💡 Frequently Asked Questions
Stemetil is indicated-
To control severe nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions.
Relieving nausea, vomiting, and attacks of dizziness or spinning sensations (vertigo) associated with Me...
Antiemetic-Children (not recommended in children
Drowsiness; jaw, neck, and back muscle spasms; fine worm-like tongue movements; rhythmic face, mouth, or jaw movements; slow or difficult speech; difficulty swallowing; restlessness and pacing; tremors; shuffling walk; skin rash; yellowing of the ski...
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